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KMID : 0363620090300020127
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Journal of Korean Oriental Medicine
2009 Volume.30 No. 2 p.127 ~ p.132
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Stability Study for Herbal Drug According to Storage Conditions and Periods
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Son Jin-Young
Shin Jang-Woo
Son Chang-Gue
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Abstract
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Objectives: This study aimed to investigate the stability of a decoction using three herbal plants and their major components according to the storage conditions and periods.
Materials and Methods: A three-herb mixture (1:1:1) of Glycyrrhiza uralensis Fischer, Artemisia capillaris Thunberg, and Poncirus trifoliata Rafinesqui was decocted and kept at room temperature (25±2℃) or cold temperature (4℃) for 0, 2, 4 or 8 weeks in liquid form in a plastic pack under dark conditions. At time points given, they were lyophilized. 200 mg of powdered samples were dissolved in 1 mL of 90% methanol and then applied to a high performance thin layer chromatography (HPTLC) with glycyrrhizin, 6,7-dimethoxycoumarin or poncirin for quantitative or qualitative analysis.
Results: There were no gross changes in HPTLC-based compositional band-patterns of the three herbal mixture according to the storage conditions and period. The major components of each herb, glycyrrhizin, 6,7-dimethoxycoumarin and poncirin, showed slight time-dependent reduction in their contents both at room and cold temperature for 8 weeks.
Conclusion: We could conclude that the current herbal decoction is generally safe for the stability at both RT or CT for at least 8 weeks. Nevertheless, we proposed that further advanced studies are required for more multiple herbal mixtures and longer storage periods.
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KEYWORD
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Stability, Oriental medicine, Decoction, Storage condition
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